Bones

Bones

Li, J., et al., Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis. BMC Musculoskelet Disord, 2017. 18(1): p. 58. Guo, J., et al., Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin. Int Orthop, 2017. 41(10): p. 2119-2128. Yamada, T., et al., Hydrogen supplementation of preservation solution improves…

Miscellaneous

Miscellaneous

Zhang, W., et al., Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo. Biomedicine & Pharmacotherapy, 2018. 106: p. 1126-1134. Xu, F., et al., Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-beta in Guinea…

Brain

Brain

Yuan, J., et al., Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. J Surg Res, 2018. 228: p. 238-246. Wu, X., et al., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res, 2018. Wang, H.,…

Cancer

Cancer

Yang, Y., Y. Zhu, and X. Xi, Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species. Oncology Letters, 2018. 16(3): p. 2771-2776. Wang, D., et al., Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018. 104: p. 788-797. Jiang, Y., et al., Therapeutic efficacy of hydrogenrich saline alone and in combination with PI3K…

Lung and Other Organs

Lung and Other Organs

Zhang, G., et al., The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period. Transplantation, 2018. 102(8): p. 1253-1261. Wu, D., et al., Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun, 2018. 495(2): p. 1620-1627. Lu, W.,…

Liver

Liver

Li, H., et al., Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. Life Sci, 2018. 194: p. 7-14. Ishikawa, T., et al., Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. Surg Today, 2018. Chen, M., et al., Hydrogen protects against liver injury…

Human Studies

Human Studies

Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051. Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492. Nakayama, M., et al., Novel haemodialysis…

Heart

Heart

Song, D., et al., Hydrogen rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep, 2018. 18(2): p. 1925-1938. Matsuoka, H., et al., Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clin Exp Hypertens, 2018: p. 1-5 Feng, R., et al., Early Aerobic…

Eye & Ear

Eye & Ear

Wu, J., et al., Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. Biochem Biophys Res Commun, 2018. 495(4): p. 2462-2468. Ogawa, H., et al., Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil. Neurosci Lett, 2018. 665: p. 195-199. Tao, Y., et al., The Comparative Efficiency…

Registered Clinical Studies

Registered Clinical Studies

Public Title Date of Registration   Effects of Hydronen Magnesium Tablets on Cardiometabolic Risk Factors and Inflammation in Subjects with Metabolic Syndrome. Hydrogen-rich Water for Non-alchoholic Fatty Liver DiseaseDouble blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the gut microbiota. 2018   Open labeled examination to observe…