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Dr. Kyu-Jae Lee, M.D., PHD.

Dr. Kyu-Jae Lee, M.D., PHD.

In the 1990’s I began studying alkaline ionized water and published scientific articles on its antioxidant, anticancer, and anti-diabetic effects, but did not really understand why the water worked. It was difficult to believe. Upon further investigation I have now confirmed that the benefits from the alkaline ionized water are attributed to the hydrogen gas produced during electrolysis. The more I research and learn about hydrogen the more dedicated and passionate I become in educating and helping others.

Career Summary

  • 1987-1993 M.B. Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Korea
  • 1995-1998 Ph.D. Department of Parasitology, Graduate School of Wong Wang College of Medicine, Iksan, Korea
  • 1993-1995 M.P.H. Department of Medicine, Graduate School of Yonsei University, Seoul, Korea
  • 2001-2005 Instructor, Department of Parasitology, Wonju College of Medicine, Yonsei University
  • 2005 -2008 Assistant Professor, Department of Parasitology, Wonju College of Medicine, Yonsei University
  • 2008-2013 Associate Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
  • 2008 – present Head Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
  • 2010-present Senior Research Fellow, Institute for Poverty Alleviation and International Development (IPAID), Yonsei University
  • 2010 – present President of The Korean Water Society
  • 2013- present Full Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
  • 2011– 2013 Project Manager of the Project “Health Services Improvement in Tikapur”. KOICA, Yonsei University & Ministry of Health and Population of Nepal
  • 2014–present Director of Roseclub International (Korean NGO)

Selected articles

TITLEJOURNALYEARGRADE
1Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic chargeInt J Nanomed2014SCIE
2positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga miceBiol Pharm Bull2014SCIE
3Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling modelIndian J Med Res2014SCIE
4The drinking effect of Gangcheon mountain spring water on diabetes patientsKorean J Waters2014
5The Biological effects of Long-term drinking Gangcheon mountain spring water on ICR mouseKorean J Waters2014
6Changing Pattern of Complementary and Alternative Medicine in Tikapur Nepal: A Hope for Future HealthAltern Integ Med2014
7The drinking effect of hydrogen water on atopic dermatitis induced by dermatophagoides farinae allergen in NC/Nga miceEvid-Based Comp Alt2013SCIE
8The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless miceMol Cell Toxicol2013SCIE
9CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathwaysMol Immunol2013SCI
10HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression
of mevalonate pathway
Cell Death Disease2013SCI
11Assessment of drinking water and sanitation habits in rural Tikapur, NepalRural Remote Health2013SSCI
12Anti-obesity effect of alkaline reduced water in high fat-fed obese miceBiol Pharm Bull2013SCIE
13Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatinCancer Cell Int2013SCIE
14Involvement of the FoxO3a pathway in the ischemia/ reperfusion injury of cardiac microvascular endothelial cellsExp Mol Pathol2013SCIE
15clinical effect and mechanism of alkaline reduced waterJ Food Drug Anal2012SCI
16Application of electrolyzed water as a useful disinfectant in developing countriesKorean J Waters2012SCIE
17evaluation of the efficiency of the urine-mda analyzer compared to TBARS malondialdehyde quantitationKorean J Waters2012
18The anti-oxidant effect of high concentrated mineral water: in vivo and in vitroKorean J Waters2012
19Tube well contamination in Tikapur, NepalKorean J Waters2012
20Bambusae caulis in Liquamen suppresses the expression of thymus and activation-regulated chemokine and macrophage-derived chemokine in
human keratinocytes due to
antioxidant effect
Evid-Based Comp Alt2012SCI
21Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless miceBiol Pharm Bull2011SCIE
22The melamine excretion effect of the electrolyzed reduced water in melamine-fed miceFood Chem Toxicol2011SCI
23The effect of extract powder of fruits and vegetables on hangoverKorean J Waters2011
24The effects of hot spring water on reactive oxygen species (ROS) in human studyKorean J Waters2011
25The bathing effect of mineral-deep water on DNCB-induced atopic dermatitis-like skin lesions in hairless miceKorean J Waters2011
26The effect of obesity inhibition on drinking of Makgeolli made by alkaline spring water in high fat diet-fed C57BL/6 miceKorean J Waters2011
27The water quality evaluation of hot spring water of Gangcheon-san, Sunchang-gun, KoreaKorean J Waters2011
28The evaluation of efficacy on oral cavity cleaner (Dental Cleaner)Korean J Waters2011
29Alkaline reduced water and its antioxidant effectKorean J Waters2011
30Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cellsToxicol Letters2010SCI
31Reactive oxygen species are involved in the IFN-r-stimulated production of Th2 chemokines in HaCaT keratinocytesJ Cell Physiol2010SCI
32Alkaline reduced waterKorean J Waters2010
33The effects of alkaline reduced water on hangover symptomKorean J Waters2010
34The effects of bath in alkaline reduced spring water on reactive oxygen species (ROS) in human studyKorean J Waters2010
35The effect of mineral induced alkaline reduced water on broiler chickenKorean J Waters2010
36The efficacy of evaluation of tourmaline-ionized water in animal studyKorean J Waters2009
37Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley ratsBiomed Res2009
38Essential involvement of cross-talk between IFN-randTNF-a in CXCL10 production in human THP-1 monocytesKorean J. Microscopy2009
39Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-?in HaCaT cells, a human keratinocyte cell lineBiomed Res -Tokyo2009SCIE
40Effects of Bambusae caulis in Liquamen on the development of atopic dermatitis-like skin lesions in hairless miceJ Cell Physiol2009SCI
41The adenylylcyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kB in HaCaT ke43ratinocytesBrit J Pharmacol2009SCI
42The Food Safety of Superfine Powder (Phellinus linteus) Processed by Nanomill in C57BL/6 MiceJ Ethnopharmacol2009SCIE
43The Anticancer Effect of Inonotus obliquus Pilat(Chaga) Processed by Nanomill Technology In VivoMol Immunol2009SCI
44Superfine saengshik improves the liver protecting effect compared with fine Saengshik in animal modelKorean J. Microscopy2009
45The food safety of superfine Saengshik processed by top-down technique in miceKorean J. Microscopy2009
46the immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 miceJ Food Sci2009SCIE
47The effects of electrolyzed reduced water on blood and organ tissues of miceKorean J Microscopy2008
48The effects of magnesium rich sea mineral water on atopic dermatitis-like skin lesions in hairless miceKorean J. Microscopy2008
49The effect of mineral-induced alkaline reduced water on the DSS-induced acute inflammatory bowel disease mouse modelKorean J. Microscopy2008
50Anticancer effect of ascorbic acid and saengshik
on CT-26 colon cancer
Korean J. Microscopy2008
51Effects of electrolyzed alkaline reduced water on Echinostoma hortense infection and immune response in C57BL/6 miceKorean J. Microscopy2008
52Ultramicroscopic investigation of the preservation status of hair collected from a full-term, intrauterine baby mummy of the Joseon Dynasty, KoreaInt J Osteoarchaeol2008SSCI
53Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortenseKorean J. Microscopy2007SCIE
54A clinical trial of orally administered alkaline reduced waterJ Exp Biomed2007SCIE
55The effects of Saengshik on the hepatotoxicity of mouse induced by carbon tetrachlorideKorean J. Microscopy2007
56Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN miceParasitol Res2007SCIE
57The liver protecting effect of pomegranate (Punica granatum) seed oil in mice treated with CCl4Korean J. Microscopy2006
58Survey report on understanding the safety and efficacy of alkaline reduced waterNewest Med2006
59Anti-diabetic effect of alkaline-reduced water on OLETF ratsBiosci Biotechnol Biochem2006SCIE
60The study on the safety of alkaline reduced water for drinking in the ICR miceNewest Med2005
61Reaction of mast cells and goblet cells in the small intestine of C57BL/6 and C3H/HeN mice infected with Echinostoma hortenseJ Exp Biomed Sci2005SCIE
62The effect of high-salted mineral water on blood pressure and sodium excretionJ Exp Biomed Sci2005SCIE
63The effects of green tea and magnessium on type 1 diabetes and liver toxicity in miceNewest Med2005
64Anticancer effect of alkaline reduced waterJ Int Soc Life info Sci2004
65The glutathione S-tranferase activity of alkaline reduced water on sprague-dawley ratsNewest Med2004
66Effect of alkali reduced water (ARW) on the lipid metabolism of ICR miceNewest Med2004
67The change of pH and oxidation-reduction potential (ORP) of alkaline reduced waterNewest Med2004
68Reactive oxygen species (ROS) scavenging effect of alkaline-reduced waterNewest Med2004