Dr. Kyu-Jae Lee, M.D., PHD.
In the 1990’s I began studying alkaline ionized water and published scientific articles on its antioxidant, anticancer, and anti-diabetic effects, but did not really understand why the water worked. It was difficult to believe. Upon further investigation I have now confirmed that the benefits from the alkaline ionized water are attributed to the hydrogen gas produced during electrolysis. The more I research and learn about hydrogen the more dedicated and passionate I become in educating and helping others.
Career Summary
- 1987-1993 M.B. Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Korea
- 1995-1998 Ph.D. Department of Parasitology, Graduate School of Wong Wang College of Medicine, Iksan, Korea
- 1993-1995 M.P.H. Department of Medicine, Graduate School of Yonsei University, Seoul, Korea
- 2001-2005 Instructor, Department of Parasitology, Wonju College of Medicine, Yonsei University
- 2005 -2008 Assistant Professor, Department of Parasitology, Wonju College of Medicine, Yonsei University
- 2008-2013 Associate Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
- 2008 – present Head Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
- 2010-present Senior Research Fellow, Institute for Poverty Alleviation and International Development (IPAID), Yonsei University
- 2010 – present President of The Korean Water Society
- 2013- present Full Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
- 2011– 2013 Project Manager of the Project “Health Services Improvement in Tikapur”. KOICA, Yonsei University & Ministry of Health and Population of Nepal
- 2014–present Director of Roseclub International (Korean NGO)
Selected articles
| TITLE | JOURNAL | YEAR | GRADE | |
|---|---|---|---|---|
| 1 | Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge | Int J Nanomed | 2014 | SCIE |
| 2 | positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice | Biol Pharm Bull | 2014 | SCIE |
| 3 | Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model | Indian J Med Res | 2014 | SCIE |
| 4 | The drinking effect of Gangcheon mountain spring water on diabetes patients | Korean J Waters | 2014 | |
| 5 | The Biological effects of Long-term drinking Gangcheon mountain spring water on ICR mouse | Korean J Waters | 2014 | |
| 6 | Changing Pattern of Complementary and Alternative Medicine in Tikapur Nepal: A Hope for Future Health | Altern Integ Med | 2014 | |
| 7 | The drinking effect of hydrogen water on atopic dermatitis induced by dermatophagoides farinae allergen in NC/Nga mice | Evid-Based Comp Alt | 2013 | SCIE |
| 8 | The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice | Mol Cell Toxicol | 2013 | SCIE |
| 9 | CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways | Mol Immunol | 2013 | SCI |
| 10 | HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway | Cell Death Disease | 2013 | SCI |
| 11 | Assessment of drinking water and sanitation habits in rural Tikapur, Nepal | Rural Remote Health | 2013 | SSCI |
| 12 | Anti-obesity effect of alkaline reduced water in high fat-fed obese mice | Biol Pharm Bull | 2013 | SCIE |
| 13 | Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin | Cancer Cell Int | 2013 | SCIE |
| 14 | Involvement of the FoxO3a pathway in the ischemia/ reperfusion injury of cardiac microvascular endothelial cells | Exp Mol Pathol | 2013 | SCIE |
| 15 | clinical effect and mechanism of alkaline reduced water | J Food Drug Anal | 2012 | SCI |
| 16 | Application of electrolyzed water as a useful disinfectant in developing countries | Korean J Waters | 2012 | SCIE |
| 17 | evaluation of the efficiency of the urine-mda analyzer compared to TBARS malondialdehyde quantitation | Korean J Waters | 2012 | |
| 18 | The anti-oxidant effect of high concentrated mineral water: in vivo and in vitro | Korean J Waters | 2012 | |
| 19 | Tube well contamination in Tikapur, Nepal | Korean J Waters | 2012 | |
| 20 | Bambusae caulis in Liquamen suppresses the expression of thymus and activation-regulated chemokine and macrophage-derived chemokine in human keratinocytes due to antioxidant effect | Evid-Based Comp Alt | 2012 | SCI |
| 21 | Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice | Biol Pharm Bull | 2011 | SCIE |
| 22 | The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice | Food Chem Toxicol | 2011 | SCI |
| 23 | The effect of extract powder of fruits and vegetables on hangover | Korean J Waters | 2011 | |
| 24 | The effects of hot spring water on reactive oxygen species (ROS) in human study | Korean J Waters | 2011 | |
| 25 | The bathing effect of mineral-deep water on DNCB-induced atopic dermatitis-like skin lesions in hairless mice | Korean J Waters | 2011 | |
| 26 | The effect of obesity inhibition on drinking of Makgeolli made by alkaline spring water in high fat diet-fed C57BL/6 mice | Korean J Waters | 2011 | |
| 27 | The water quality evaluation of hot spring water of Gangcheon-san, Sunchang-gun, Korea | Korean J Waters | 2011 | |
| 28 | The evaluation of efficacy on oral cavity cleaner (Dental Cleaner) | Korean J Waters | 2011 | |
| 29 | Alkaline reduced water and its antioxidant effect | Korean J Waters | 2011 | |
| 30 | Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells | Toxicol Letters | 2010 | SCI |
| 31 | Reactive oxygen species are involved in the IFN-r-stimulated production of Th2 chemokines in HaCaT keratinocytes | J Cell Physiol | 2010 | SCI |
| 32 | Alkaline reduced water | Korean J Waters | 2010 | |
| 33 | The effects of alkaline reduced water on hangover symptom | Korean J Waters | 2010 | |
| 34 | The effects of bath in alkaline reduced spring water on reactive oxygen species (ROS) in human study | Korean J Waters | 2010 | |
| 35 | The effect of mineral induced alkaline reduced water on broiler chicken | Korean J Waters | 2010 | |
| 36 | The efficacy of evaluation of tourmaline-ionized water in animal study | Korean J Waters | 2009 | |
| 37 | Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats | Biomed Res | 2009 | |
| 38 | Essential involvement of cross-talk between IFN-randTNF-a in CXCL10 production in human THP-1 monocytes | Korean J. Microscopy | 2009 | |
| 39 | Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-?in HaCaT cells, a human keratinocyte cell line | Biomed Res -Tokyo | 2009 | SCIE |
| 40 | Effects of Bambusae caulis in Liquamen on the development of atopic dermatitis-like skin lesions in hairless mice | J Cell Physiol | 2009 | SCI |
| 41 | The adenylylcyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kB in HaCaT ke43ratinocytes | Brit J Pharmacol | 2009 | SCI |
| 42 | The Food Safety of Superfine Powder (Phellinus linteus) Processed by Nanomill in C57BL/6 Mice | J Ethnopharmacol | 2009 | SCIE |
| 43 | The Anticancer Effect of Inonotus obliquus Pilat(Chaga) Processed by Nanomill Technology In Vivo | Mol Immunol | 2009 | SCI |
| 44 | Superfine saengshik improves the liver protecting effect compared with fine Saengshik in animal model | Korean J. Microscopy | 2009 | |
| 45 | The food safety of superfine Saengshik processed by top-down technique in mice | Korean J. Microscopy | 2009 | |
| 46 | the immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice | J Food Sci | 2009 | SCIE |
| 47 | The effects of electrolyzed reduced water on blood and organ tissues of mice | Korean J Microscopy | 2008 | |
| 48 | The effects of magnesium rich sea mineral water on atopic dermatitis-like skin lesions in hairless mice | Korean J. Microscopy | 2008 | |
| 49 | The effect of mineral-induced alkaline reduced water on the DSS-induced acute inflammatory bowel disease mouse model | Korean J. Microscopy | 2008 | |
| 50 | Anticancer effect of ascorbic acid and saengshik on CT-26 colon cancer | Korean J. Microscopy | 2008 | |
| 51 | Effects of electrolyzed alkaline reduced water on Echinostoma hortense infection and immune response in C57BL/6 mice | Korean J. Microscopy | 2008 | |
| 52 | Ultramicroscopic investigation of the preservation status of hair collected from a full-term, intrauterine baby mummy of the Joseon Dynasty, Korea | Int J Osteoarchaeol | 2008 | SSCI |
| 53 | Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense | Korean J. Microscopy | 2007 | SCIE |
| 54 | A clinical trial of orally administered alkaline reduced water | J Exp Biomed | 2007 | SCIE |
| 55 | The effects of Saengshik on the hepatotoxicity of mouse induced by carbon tetrachloride | Korean J. Microscopy | 2007 | |
| 56 | Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN mice | Parasitol Res | 2007 | SCIE |
| 57 | The liver protecting effect of pomegranate (Punica granatum) seed oil in mice treated with CCl4 | Korean J. Microscopy | 2006 | |
| 58 | Survey report on understanding the safety and efficacy of alkaline reduced water | Newest Med | 2006 | |
| 59 | Anti-diabetic effect of alkaline-reduced water on OLETF rats | Biosci Biotechnol Biochem | 2006 | SCIE |
| 60 | The study on the safety of alkaline reduced water for drinking in the ICR mice | Newest Med | 2005 | |
| 61 | Reaction of mast cells and goblet cells in the small intestine of C57BL/6 and C3H/HeN mice infected with Echinostoma hortense | J Exp Biomed Sci | 2005 | SCIE |
| 62 | The effect of high-salted mineral water on blood pressure and sodium excretion | J Exp Biomed Sci | 2005 | SCIE |
| 63 | The effects of green tea and magnessium on type 1 diabetes and liver toxicity in mice | Newest Med | 2005 | |
| 64 | Anticancer effect of alkaline reduced water | J Int Soc Life info Sci | 2004 | |
| 65 | The glutathione S-tranferase activity of alkaline reduced water on sprague-dawley rats | Newest Med | 2004 | |
| 66 | Effect of alkali reduced water (ARW) on the lipid metabolism of ICR mice | Newest Med | 2004 | |
| 67 | The change of pH and oxidation-reduction potential (ORP) of alkaline reduced water | Newest Med | 2004 | |
| 68 | Reactive oxygen species (ROS) scavenging effect of alkaline-reduced water | Newest Med | 2004 |