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Registered Clinical Studies

Public Title Date of Registration   Effects of Hydronen Magnesium Tablets on Cardiometabolic Risk Factors and Inflammation in Subjects with Metabolic Syndrome. Hydrogen-rich Water for Non-alchoholic Fatty Liver DiseaseDouble blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the gut microbiota. 2018   Open labeled examination to observe…

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Kidney | Molecular Hydrogen Research Articles

Nakayama, M., et al., Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep, 2018. 8(1): p. 254. Hosgood, S.A., et al., Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. Artif Organs, 2018. Cheng, T.C., et al., Nephroprotective effect of electrolyzed…

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Ischemia/Reperfusion Injuries

Liu, H., et al., Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion Hinjury. Mol Med Rep, 2015. 12(2): p. 2495-502. Huang, T., et al., Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res, 2015. 194(2): p. 471-80. Zhou, L., et al., Beneficial effects of hydrogen-rich saline…

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Hydrogen From Bacteria

Liu, C., et al., Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. Sci Rep, 2014. 4: p. 5485. Zhai, X., et al., Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. Free Radic Biol Med, 2013. 65: p. 731-41. Shimouchi,…

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Hydrogen Chemistry/Physics

Kurokawa, R., et al., Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation. Med Gas Res, 2015. 5: p. 13. Akhavan, O., et al., Hydrogen-rich water for green reduction of graphene oxide suspensions. International Journal of Hydrogen Energy, 2015. 40(16): p. 5553-5560. Seo, T., R. Kurokawa, and B. Sato, A convenient method for determining the concentration of…

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Hydrogen Review Articles

Zhang, Y., et al., Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside. Cell Physiol Biochem, 2018. 47(1): p. 1-10. Sano, M., et al., Promising novel therapy with hydrogen gas for emergency and critical care medicine. Acute Med Surg, 2018. 5(2): p. 113-118. Yoritaka, A., et al., Erratum to: A randomized double-blind multi-center trial of hydrogen…

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Sepsis, Gastritis, Intestine

Zheng, W., et al., Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet. Toxins (Basel), 2018. 10(6). Xiao, H.W., et al., Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota. Exp Mol Med, 2018. 50(1): p. e433. Nishimura, N., et al., Transplantation of High…

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Spine and Pancreas | Molecular Hydrogen Research Articles

Chen, X., et al., Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. Cell Physiol Biochem, 2018. 47(1): p. 176-190. Chen, L., et al., Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss. Cell Physiol Biochem, 2017….

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Metabolic Syndrome | Molecular Hydrogen Research Articles

Zhang, X., et al., Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig, 2018. 9(1): p. 83-90. Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 2017. Hou, C., et al., Coral calcium hydride prevents hepatic steatosis in…

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Pain and Others | Molecular Hydrogen Research Articles

449.Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015. 450.Chen, Q., et al., Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci, 2013. 40(6): p. 857-63. 451.Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition…