Diagram of lungs with red and blue coloring

Lung and Other Organs

Zhang, G., et al., The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period. Transplantation, 2018. 102(8): p. 1253-1261. Wu, D., et al., Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun, 2018. 495(2): p. 1620-1627. Lu, W.,…

Diagram of the human body with a blue outline and a red liver

Liver | Molecular Hydrogen Research Articles

Li, H., et al., Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. Life Sci, 2018. 194: p. 7-14. Ishikawa, T., et al., Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. Surg Today, 2018. Chen, M., et al., Hydrogen protects against liver injury…

Graphic depicting human studies with a blue color scheme

Human Studies | Molecular Hydrogen Research Articles

Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051. Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492. Nakayama, M., et al., Novel haemodialysis…

Image of a blue-colored heart

Heart | Molecular Hydrogen Research Articles

Song, D., et al., Hydrogen rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep, 2018. 18(2): p. 1925-1938. Matsuoka, H., et al., Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clin Exp Hypertens, 2018: p. 1-5 Feng, R., et al., Early Aerobic…

Graphic or image of hydrogen molecules in a dumble-like structure
|

Hydrogen: An Emerging Medical Gas

INTRODUCTION Molecular hydrogen (i.e. H2 gas) is gaining significant attention from academic researchers, medical doctors, and physicians around the world for its recently reported therapeutic potential [1]. One of the earliest publications on hydrogen as a medical gas was in 1975, by Dole and colleagues from Baylor University and Texas A&M [2]. They reported in the journal Science that…

Close-up image of an eye

Eye and Ear | Molecular Hydrogen Research Articles

Wu, J., et al., Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. Biochem Biophys Res Commun, 2018. 495(4): p. 2462-2468. Ogawa, H., et al., Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil. Neurosci Lett, 2018. 665: p. 195-199. Tao, Y., et al., The Comparative Efficiency…

Graphic depicting clinical studies

Registered Clinical Studies

Public Title Date of Registration   Effects of Hydronen Magnesium Tablets on Cardiometabolic Risk Factors and Inflammation in Subjects with Metabolic Syndrome. Hydrogen-rich Water for Non-alchoholic Fatty Liver DiseaseDouble blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the gut microbiota. 2018   Open labeled examination to observe…

Image or diagram of a human kidney

Kidney | Molecular Hydrogen Research Articles

Nakayama, M., et al., Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep, 2018. 8(1): p. 254. Hosgood, S.A., et al., Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. Artif Organs, 2018. Cheng, T.C., et al., Nephroprotective effect of electrolyzed…

Graphic depicting ischemia/reperfusion injuries

Ischemia/Reperfusion Injuries

Liu, H., et al., Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion Hinjury. Mol Med Rep, 2015. 12(2): p. 2495-502. Huang, T., et al., Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res, 2015. 194(2): p. 471-80. Zhou, L., et al., Beneficial effects of hydrogen-rich saline…